Psoralen toxicity occurs when compounds called psoralens, found in certain plants and medications, cause harmful effects on the body. Psoralens are often used in combination with ultraviolet (UV) light for medical treatments like PUVA therapy, commonly used for psoriasis or vitiligo. However, excessive exposure to psoralens can lead to side effects such as skin sensitivity, burns, or phototoxic reactions when the skin is exposed to sunlight. Ingesting high amounts of psoralen-rich plants, such as citrus fruits like bergamot or celery, can also cause toxicity. Symptoms may include nausea, vomiting, headaches, and severe skin reactions. Proper medical supervision is essential to avoid complications.
