When discussing antitrypsin (Alpha-1 Antitrypsin, or AAT) and erythema nodosum, it typically refers to Alpha-1 Antitrypsin Deficiency (AATD) Panniculitis.
Because AAT deficiency causes an imbalance in enzymes (like elastase) that break down tissue, it can result in inflammation of the subcutaneous fat. This condition is frequently misdiagnosed as classic erythema nodosum, but they are distinctly different conditions.